I’ve had occasion recently to implement many vSphere 4.1 environments for a customer. There’s a lot to learn during these deployments and many worthy blog posts are just waiting to be written. But one especially comes to mind mainly because of its temporal relation to a recent query I had regarding a BIOS setting for a Dell PowerEdge R710. The exact query doesn’t matter, but what’s important is that I ran across Marek.Z’s blog, Default Reasoning, and this post in search of an answer. His post regarding vSphere 4.x BIOS settings and best practices interested me in writing a BIOS best practices post for vSphere 5. This is going to be very similar to vSphere 4.x, but you’ll notice I’ve included explanations as to why these settings are best suited to vSphere 5 environments. Some of these settings may be obvious, while others, like NUMA, C1E, and Memory, may not be. Especially for these, I’ve included the results of my research.